专利摘要:
The invention relates to a novel metabolite, M.139603, of the empirical formula C35H53O8Na, which is obtained from the aerobic fermentation of a novel Streptomyces species, NCIB 11426, and to the corresponding free acid form thereof, C35H54O8. M.139,603 reduces the proportion of methane produced by the "digestion" of food in the rumen of ruminant animals and increases the proportion of propionate to acetate in the rumen contents. The compound is therefore useful for increasing the growth rate of ruminant animals, and/or for increasing their efficiency of food conversion. The compound also possesses activity against Gram positive micro-organisms, and against coccidia, for example Eimeria tenella.
公开号:SU1324575A3
申请号:SU802949055
申请日:1980-07-15
公开日:1987-07-15
发明作者:Хью Дэвис Дэвид;Лайтфут Флайд Норрис Джоффри
申请人:Империал Кемикал Индастриз Лимитед (Фирма);
IPC主号:
专利说明:

S.% 0, Na
H 8.8% (pac- .C 67.3;
113
This invention relates to the feeding of farm animals, in particular using an antibiotic as a feed additive.
The purpose of the invention is to increase the efficiency of the method of fattening cattle.
In the proposed method, an antibiotic M. 139.603 is used as a feed additive. It has the following properties.
Molecular formula C determined by mass spectrometry for a molecular ion with a mass of 624.361 (calculated for Cj, .. HjjOjNa 624.364) and according to the results of the analysis: C 67.55 read for H 8.5. %):
The infrared spectrum has the following characteristics: 3300, 1725, 1645, 1565 and 915 cm-
The ultraviolet spectrum in the ethanol solution has the following characteristic absorption bands: 234 nm (e 12900) and 272 nm (10800). . Melting point 176-178 ° C.
The proposed compound promotes an increase in the amount of propionic acid in the gastric juice of the rumen, in particular, an increase in the amount of propionic acid by reducing the proportion of methane and / or acetic acid. This is known to be a positive factor when feeding ruminants, since propionic acid is a much more efficient precursor to the formation of glucose, from which animals form their energy and due to which they grow.
Example. For carrying out the method, antibiotic M.139.603 is added to the feed used and fed to cattle in an amount of 0.05-0.5 mg / kg body weight per day during the entire period of their growth or only during part of this period as a starting one. diets for young animals or final diets for animals approaching slaughter weight.


Suitable cattle feeds include the following formulations:
briquette
flour flour
Centners
10.25
one
with
c
five
0
five
Peeled Ground Nut Cake
Flaked flaxseed meal
Cake extracted flaxseed Wheat food Feather flour Flour from seaweed
Kostna flour Mel
Feed Treacle Vitamins and Traces of Mineral Mix
Barley flour Wheat flour Cake peeled ground walnut
Extracted Ground Nut Cake
Kostna flour Mel
Salt
0
Feed Treacle Urea
Vitamins and traces of mineral mixture
one
1 3 0.25
0.25 - 0.25 - 0.25 1.5
0.25
eleven
5.25
0.25
42 pounds 191 cents
0.25
42 pounds 0.191 cents 14 pounds 0.064 cents
2
0.25
14 pounds
0.064
cent
about
40
Comparative data obtained during fattening of cattle using monensin and M.139.603 as a feed additive are presented in the table,
The table shows that M.139.603 is superior to monensin in almost all ways. The daily increase in live weight is significantly better with all concentrations of 45, as well as the consumption of feed injected per unit of weight gain.
权利要求:
Claims (1)
[1]
Invention Formula
The method of fattening cattle by giving food with an antibiotic, characterized in that, to increase the efficiency of the method, the antibiotic M.139.603 at a dose of 0.05-0.5 mg / kg body weight per day is used as an antibiotic. the entire period of growth or in the form of a starting diet or in the final period of fattening.
Editor N. Kishtulints
Order 2974/58 Circulation 530 Subscription
.VNIIPI USSR State Committee
for inventions and discoveries 113035, Moscow, Zh-35, Raushsk nab., 4/5
Production and printing company, Uzhgorod, st. Project, 4
Compiled by I. Tareeva
Tehred V.Glushchenko Proofreader G. Reshetnik
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同族专利:
公开号 | 公开日
YU188079A|1983-02-28|
IL57919D0|1979-11-30|
AT366892B|1982-05-10|
MY8500754A|1985-12-31|
SE7906553L|1980-02-04|
RO79259A|1982-06-25|
DK151257B|1987-11-16|
DK151257C|1988-05-09|
FI792420A|1980-02-04|
SE447910B|1986-12-22|
FI66184B|1984-05-31|
CH649780A5|1985-06-14|
AU530316B2|1983-07-14|
FR2433578B1|1983-02-04|
US4279894A|1981-07-21|
ATA531779A|1981-11-15|
JPS5551097A|1980-04-14|
NO792537L|1980-02-05|
HK26185A|1985-04-12|
PL217506A1|1982-06-21|
SE447910C|1996-02-01|
FI66184C|1984-09-10|
FR2433578A1|1980-03-14|
BG40659A3|1987-01-15|
CA1142107A|1983-03-01|
IT7949943D0|1979-08-02|
NL7905979A|1980-02-05|
CS221514B2|1983-04-29|
YU42489B|1988-10-31|
BE878042A|1980-02-04|
DE2954593C2|1988-11-10|
DE2931082A1|1980-02-21|
ZA793772B|1980-09-24|
AU4919479A|1980-02-07|
HU179207B|1982-09-28|
PL130950B1|1984-09-29|
ZW13679A1|1981-02-18|
AT367450B|1982-07-12|
NO156201B|1987-05-04|
IL57919A|1983-02-23|
DE2931082C2|1989-12-21|
KE3433A|1984-08-17|
IE791403L|1980-02-03|
PT70023A|1979-09-01|
IT1162363B|1987-03-25|
SG54784G|1985-03-08|
ATA160081A|1981-10-15|
DK325179A|1980-02-04|
IE48204B1|1984-10-31|
JPS6254307B2|1987-11-13|
NO156201C|1987-08-19|
SU1212328A3|1986-02-15|
NZ191105A|1983-03-15|
引用文献:
公开号 | 申请日 | 公开日 | 申请人 | 专利标题

EP0070622B1|1981-07-16|1987-01-14|Imperial Chemical Industries Plc|Derivatives of m.139,603 useful as growth promotors|
JPS60141293A|1983-12-28|1985-07-26|Kitasato Inst:The|Novel carcinostatic antibiotic substance 81-484 and its production|
AU581691B2|1985-10-14|1989-03-02|Balfour Manufacturing Company Limited|Process for the production of feedstuffs|
US4675270A|1986-02-10|1987-06-23|LoctiteLimited|Imaging method for vapor deposited photoresists of anionically polymerizable monomer|
US5023086A|1987-03-13|1991-06-11|Micro-Pak, Inc.|Encapsulated ionophore growth factors|
US4876273A|1987-08-13|1989-10-24|Eli Lilly And Company|Antibotic A80577 and process for its production|
US5985907A|1998-08-12|1999-11-16|Health Research, Inc.|Method for inhibiting growth of methanogens|
法律状态:
优先权:
申请号 | 申请日 | 专利标题
GB7832172|1978-08-03|LV930374A| LV5161A3|1978-08-03|1993-05-18|Saturation for fattening of cattle|
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